Proteomics Projects: HuPI focuses on protein interactions

ESF Workshop ‘Proteomics: Focus on Protein Interactions’

Approximately 70 scientists met, from May 11–13 2001, in Villa Mondragone in the hills south of Rome to discuss strategies to describe the complete protein interaction network inside a cell. Very few of the participants still needed to be convinced that this is an essential step if we want to try to interpret the functional information contained in genomic databases. This was well accepted befo...

Poxvirus proteomics and virus-host protein interactions.

Studies of the functional proteins encoded by the poxvirus genome provide information about the composition of the virus as well as individual virus-virus protein and virus-host protein interactions, which provides insight into viral pathogenesis and drug discovery. Widely used proteomic techniques to identify and characterize specific protein-protein interactions include yeast two-hybrid studi...

Label-free quantitative proteomics trends for protein-protein interactions.

Understanding protein interactions within the complexity of a living cell is challenging, but techniques coupling affinity purification and mass spectrometry have enabled important progress to be made in the past 15 years. As identification of protein-protein interactions is becoming easier, the quantification of the interaction dynamics is the next frontier. Several quantitative mass spectrome...

Attention focuses on autism.

Discovering Domains Mediating Protein Interactions

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...